*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TZ1400000 CHEMICAL NAME : 1,2-Propanediol, 3-(p-tolyloxy)- CAS REGISTRY NUMBER : 17131-24-7 BEILSTEIN REFERENCE NO. : 1949212 REFERENCE : 4-06-00-02107 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C10-H14-O3 MOLECULAR WEIGHT : 182.24 WISWESSER LINE NOTATION : Q1YQ1OR D1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 3-(p-Tolyloxy)-1,2-propanediol *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 285 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29QHAQ "Principles of Medicinal Chemistry," Foye, W.O., et al., eds., Philadelphia, Lea & Febiger, 1974 Volume(issue)/page/year: -,244,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1274 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,470,1948 *** END OF RECORD ***