*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TZ2580000
CHEMICAL NAME           : 1,3-Propanedisulfonic acid,
                          1,1'-(sulfonylbis(p-phenyleneimino))bis(3-phenyl-,
                          tetrasodium salt
CAS REGISTRY NUMBER     : 133-65-3
LAST UPDATED            : 199512
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C30-H28-N2-O14-S5.4Na
MOLECULAR WEIGHT        : 892.86
WISWESSER LINE NOTATION : WSO&YR&1YSWO&MR DSWR DMYSWO&1YR&SWO &-NA- 4
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4,4'-Diamino-diphenyl-sulfon-di-(3-phenyl-propan-1,3-disulfonat)natrium  
   (1:4)
   * Solasulfone
   * Sulfetrone
   * Sulphetrone
   * Sulphetrone tetrasodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,213,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTUA4 American Review of Tuberculosis.  (New York, NY)  V.1-70, 1917-54.
   For publisher information, see ARDSBL.  Volume(issue)/page/year: 60,62,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 3,15,1948
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/kg/40D-C
TOXIC EFFECTS :
   Blood - microcytosis with or without anemia
   Related to Chronic Data - death
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 3,15,1948
 
                            *** END OF RECORD ***