*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UA2474000
CHEMICAL NAME : Propanoic acid, 2-(4-(2-methylpropyl)phenyl)-,
2-(4-(3-chlorophenyl)-1-piperazinyl) ethyl ester,
hydrochloride
CAS REGISTRY NUMBER : 96128-90-4
LAST UPDATED : 199109
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C25-H33-Cl-N2-O2.Cl-H
MOLECULAR WEIGHT : 465.51
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 2-(4-(m-Chlorophenyl)-1-piperazinyl)ethyl(+-)-p-isobutylhydratropate
hydrochloride
* 2-(4-(3-Chlorophenyl)-1-piperazinyl)ethyl(+-)-2-(4-isobutylphenyl)propio
nate hydrochloride
* Lobuprofen hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3350 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
13,314,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1929 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
13,314,1988
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >2400 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
13,314,1988
*** END OF RECORD ***