*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UA2451500
CHEMICAL NAME           : Propanoic acid,
                          2-(((1-(2-amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sul
                          fo-3-azetidinyl)amino )-
                          2-oxoethylidine)amino)oxy)-2-methyl-,
                          (2S-(2-alpha,3-beta(Z)))-, disodium salt
CAS REGISTRY NUMBER     : 80581-86-8
LAST UPDATED            : 199606
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H15-N5-O8-S2.2Na
MOLECULAR WEIGHT        : 479.43
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Azactam disodium
   * Azthreonam disodium
   * Aztreonam disodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   8(Suppl E),141,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   8(Suppl E),141,1981
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18600 mg/kg/31D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - changes in liver weight
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   8(Suppl E),141,1981
 
                            *** END OF RECORD ***