*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC0175000
CHEMICAL NAME           : 2-Propanol, 1,1,1-trichloro-2-methyl-
CAS REGISTRY NUMBER     : 57-15-8
BEILSTEIN REFERENCE NO. : 0878167
REFERENCE               : 4-01-00-01629 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C4-H7-Cl3-O
MOLECULAR WEIGHT        : 177.46
WISWESSER LINE NOTATION : QX1&1&XGGG
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Acetone chloroform
   * Anhydrous chlorobutanol
   * Chlorbutanol
   * Chlorbutol
   * Chloretone
   * Chlorobutanol
   * Chlorobutanol, anhydrous
   * Clortran
   * Coliquifilm
   * Methaform
   * 2-Propanol, 2-methyl-1,1,1-trichloro-
   * Sedaform
   * Trichloro-tert-butanol
   * Trichloro-t-butyl alcohol
   * beta,beta,beta-Trichloro-tert-butyl alcohol
   * t-Trichlorobutyl alcohol
   * HCP
   * 1,1,1-Trichloro-2-methyl-2-propanol
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 850 ug
REACTION SEVERITY       : Mild
REFERENCE :
   XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
   Development Reports. (Rochester, NY)  Volume(issue)/page/year: MDDC-1715
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 9180 ug/30S
REACTION SEVERITY       : Mild
REFERENCE :
   XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
   Development Reports. (Rochester, NY)  Volume(issue)/page/year: MDDC-1715
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 238 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 8,77,1901
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 213 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 8,77,1901
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Vascular - regional or general arteriolar or venous dilation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 8,77,1901
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,91,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T1007
       No. of Facilities: 798 (estimated)
       No. of Industries: 3
       No. of Occupations: 13
       No. of Employees: 25038 (estimated)
       No. of Female Employees: 21000 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***