*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC1935000
CHEMICAL NAME           : 1-Propanone,
                          1-(10-(2-dimethylaminopropyl)-phenothiazin-2-yl)-,
                          maleate
CAS REGISTRY NUMBER     : 3568-23-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H24-N2-O-S.C4-H4-O4
MOLECULAR WEIGHT        : 456.60
WISWESSER LINE NOTATION : T C666 BN ISJ BY1&1N1&1 GV2 &QV1U1VQ -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 10-Dimethylaminoisopropyl-2-propionylphenothiazine maleate
   * 1-(10-(2-Dimethylaminopropyl)-phenothiazin-2-yl)-1-propanone maleate
   * 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine maleate
   * Dorevane
   * Indorm
   * Phenoctyl
   * Propavan
   * Propiomazine maleate
   * 3-Propionyl-10-dimethylamino-isopropylphenothiazine maleate
   * Propionylpromethazine maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,78,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 288 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 119,367,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,78,1959
 
                            *** END OF RECORD ***