*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC2984000
CHEMICAL NAME           : 1-Propanone,
                          1-(4-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phe
                          nyl)-
CAS REGISTRY NUMBER     : 34675-77-9
BEILSTEIN REFERENCE NO. : 0578135
REFERENCE               : 5-23-02-00114 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H28-N2-O3
MOLECULAR WEIGHT        : 368.52
WISWESSER LINE NOTATION : T6N DNTJ A1YQ1OR DV2& DR
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Centropazine
   * 1-(4-(2-Hydroxy-3-(4-phenyl-1-piperazinyl)propoxy)phenyl)-1-propanone
   * 4'-(2-Hydroxy-3-(4-phenylpiperazin-1-yl)propoxy)propiophenone
   * 3-(4-Phenylpiperazinyl)-1-(4-propionylphenoxy)propan-2-ol
   * Propiophenone, 4'-(2-hydroxy-3-(4-phenylpiperazinyl)propoxy)-
   * 1-(p-Propionylphenoxy)-3-(4-phenylpiperazinyl)-2-propanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1710 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,338,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,286,1972
 
                            *** END OF RECORD ***