*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UC3060000
CHEMICAL NAME           : 1-Propanone, 2-methyl-1,2-di-3-pyridyl-, tartrate
                          (1:2)
CAS REGISTRY NUMBER     : 908-35-0
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C14-H14-N2-O.2C4-H6-O6
MOLECULAR WEIGHT        : 526.50
WISWESSER LINE NOTATION : T6NJ CX1&1&V- CT6NJ &OVYQYQVO
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-Methyl-1,2-dipyridyl-3'-1-oxopropane ditartrate
   * 2-Methyl-1,2-di-3-pyridyl-1-propanone tartrate (1:2)
   * Metopirone ditartrate
   * Metyprapone bitartrate
   * Metyrapone ditartrate
   * Metyrapone tartrate
   * Su 4885 ditartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 17,73,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 261 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,537,1972
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 40,451,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 40,451,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 200 mg/kg
SEX/DURATION            : female 30-31 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   BNEOBV Biology of the Neonate.  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.15-    1970-  Volume(issue)/page/year: 27,1,1975
 
                            *** END OF RECORD ***