*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UB6655000
CHEMICAL NAME           : 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-,
                          (+-)-
CAS REGISTRY NUMBER     : 21870-06-4
LAST UPDATED            : 199706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C14-H20-N2-O2
MOLECULAR WEIGHT        : 248.36
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (+-)-1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol
   * LB 46
   * (+-)-LB 46
   * DL-LB46
   * (+-)-Pindolol
   * dl-Pindolol
   * DL-Pindolol
   * (RS)-Pindolol
   * 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-, (+-)-
   * Visken
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 199,79,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 166 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IJPPAZ Indian Journal of Physiology and Pharmacology.  (All India Institute
   of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029,
   India)  V.1-    1957-  Volume(issue)/page/year: 17,235,1973
 
                            *** END OF RECORD ***