*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UE3865050
CHEMICAL NAME           : Propionamide,
                          2-(dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 20170-21-2
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C20-H22-N4-O.xCl-H
MOLECULAR WEIGHT        : 589.68
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Difenamizole hydrochloride
   * 1,3-Diphenyl-5-(2-dimethylaminopropionamide)pyrazole hydrochloride
   * Propanamide, 2-(dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)-,  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 396 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 560 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 186 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GDIKAN Gifu Daigaku Igakubu Kiyo.  Papers of the Gifu University School of
   Medicine.  (Gifu Daigaku Igakubu, 40 Tsukasa-machi, Gifu 500, Japan)  V.15-
   1967-  Volume(issue)/page/year: 20,360,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 92700 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65,529,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   69,679,1973
 
                            *** END OF RECORD ***