*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UE6050000
CHEMICAL NAME           : Propionic acid,
                          3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methy
                          l-
CAS REGISTRY NUMBER     : 16034-77-8
BEILSTEIN REFERENCE NO. : 2171366
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H13-I3-N2-O3
MOLECULAR WEIGHT        : 613.97
WISWESSER LINE NOTATION : ZR BI DI FI CNV1&1Y1&VQ
SYNONYMS/TRADE NAMES :
   * N-Acetyl-N-(3-amino-2,4,6-triiodophenyl)-beta-aminoisobutyric acid
   * 3-(Acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methylpropanoic acid
   * N-Acetyl-N-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine
   * N-Acetyl-N-(2,4,6-triiodo-3-aminophenyl)-beta-aminoisobutyric acid
   * Cholebrine
   * Cholimil
   * DRC 1201
   * Iocetamic acid
   * MP 620
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,232,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Gastrointestinal - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,232,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 410 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,997,1970

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X6131
       No. of Facilities: 10 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 260 (estimated)
       No. of Female Employees: 140 (estimated)

 
                            *** END OF RECORD ***