*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UF6125000
CHEMICAL NAME           : Propionic acid,
                          2-methyl-2-(p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy)
                          -
CAS REGISTRY NUMBER     : 3771-19-5
BEILSTEIN REFERENCE NO. : 2005820
LAST UPDATED            : 199612
DATA ITEMS CITED        : 21
MOLECULAR FORMULA       : C20-H22-O3
MOLECULAR WEIGHT        : 310.42
WISWESSER LINE NOTATION : L66&TJ GR DOX1&1&VQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * CH 13-437
   * Ciba 13437 SU
   * C 13437 SU
   * 2-Methyl-2-(4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy)propanoic acid
   * alpha-Methyl-alpha-(p-1,2,3,4-tetrahydronaphth-1-ylphenoxy)propionic acid
   * 2-Methyl-2-(p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy)propionic acid
   * 2-Methyl-2-(4-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy)propanoic acid
   * Melipan
   * Nafenoic acid
   * Nafenopin
   * SU-13437
   * TPIA
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 gm/kg/92W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Liver - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   59,1645,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 gm/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,1211,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,1211,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 41300 mg/kg/59W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   50,3701,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 30 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,135,1993
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 mg/L
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 44,823,1988
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,1033,1984
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1400 mg/kg/7D (Continuous)
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 42,678,1986
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 32 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   41,310,1991
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 210 mg/kg/1W (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,1557,1991
 
TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,3,1988
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,135,1993
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 30 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 286,135,1993
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,36,1980
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Primate - monkey Liver
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CBRPDS Cell Biology International Reports.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1977-  Volume(issue)/page/year:
   12,1077,1988

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 24,125,1980

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 24,125,1980

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   APLMAS Archives of Pathology and Laboratory Medicine.  (AMA, 535 N. Dearborn
   St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100-    1976-
   Volume(issue)/page/year: 107,54,1983

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***