*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UF7990000
CHEMICAL NAME           : Propionic acid, 3,3'-thiodi-
CAS REGISTRY NUMBER     : 111-17-1
LAST UPDATED            : 199707
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C6-H10-O4-S
MOLECULAR WEIGHT        : 178.22
WISWESSER LINE NOTATION : QV2S2VQ
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Bis(2-carboxyethyl) sulfide
   * Diethyl sulfide 2,2'-dicarboxylic acid
   * Kyselina beta,beta'-thiodipropionova
   * Kyselina 3,3-thiodipropionova
   * Propanoic acid, 3,3'-thiobis-
   * Sulfide, bis(2-carboxyethyl)
   * TDPA
   * 4-Thiaheptanedioic acid
   * Thiodihydracrylic acid
   * Thiodipropionic acid
   * beta,beta'-Thiodipropionic acid
   * 3,3'-Thiodipropionic acid
   * Tyox A
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,998,1986
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/24H
REACTION SEVERITY       : Moderate
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,998,1986
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 11,25,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFREAW Advances in Food Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-32, 1948-88.  Volume(issue)/page/year: 3,197,1951

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1233
       No. of Facilities: 28 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1288 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1233
       No. of Facilities: 8 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 787 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***