*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UH1599500
CHEMICAL NAME           : Propiophenone,
                          2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 10402-53-6
LAST UPDATED            : 199503
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C24-H32-N2-O2.2Cl-H
MOLECULAR WEIGHT        : 453.50
WISWESSER LINE NOTATION : T6N DNTJ A1Y1&VR& D1YR&O2 &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(2-Benzoylpropyl)-2-(2-ethoxy-2-phenylethyl)piperazine dihydrochloride
   * 746 CE
   * Eftapan
   * Eprazinone dihydrochloride
   * Eprazinone hydrochloride
   * 2-(4-(beta-Ethoxyphenethyl)-1-piperazinylmethyl)propiophenone  
   dihydrochloride
   * 3-(4-(beta-Ethoxyphenethyl)-1-piperazinyl)-2-methyl-1-propiophenone  
   dihydrochloride
   *   3-(4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propano
     ne dihydrochloride
   * Mucitux
   * 1-(2-Phenyl-2-ethoxy)ethyl-4-(2-benzyloxy)propylpiperazine  
   dihydrochloride
   * Resplen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 763 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 191 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 238 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 286 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 116 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCIPDV Beijing Yixueyuan Xuebao.  Journal of Peking Medical College.
   (Beijing Yixueyuan, Beijiaohaidianqu, Beijing, Peop. Rep. China)
   19??-V.17(3), 1985.  Volume(issue)/page/year: 13(2),98,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 2,314,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCIPDV Beijing Yixueyuan Xuebao.  Journal of Peking Medical College.
   (Beijing Yixueyuan, Beijiaohaidianqu, Beijing, Peop. Rep. China)
   19??-V.17(3), 1985.  Volume(issue)/page/year: 13(2),98,1981
 
                            *** END OF RECORD ***