*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UH4410000
CHEMICAL NAME           : Propiophenone, 3-piperidino-, hydrochloride
CAS REGISTRY NUMBER     : 886-06-6
LAST UPDATED            : 199403
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H19-N-O.Cl-H
MOLECULAR WEIGHT        : 253.80
WISWESSER LINE NOTATION : T6NTJ A2VR &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(beta-Benzoylethyl)piperidine hydrochloride
   * CV-950
   * NA 65 hydrochloride
   * 1-Phenyl-3-piperidinopropan-1-one hydrochloride
   * 1-Phenyl-3-(1-piperidinyl)-1-propanone hydrochloride
   * beta-Piperidinopropiophenone hydrochloride
   * 3-Piperidinopropiophenone hydrochloride
   * beta-(1-Piperidyl)propiophenone hydrochloride
   * 1-Propanone, 1-phenyl-3-piperidino-, hydrochloride
   * 1-Propanone, 1-phenyl-3-(1-piperidinyl)-, hydrochloride
   * Propiophenone, beta-piperidino-, hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 99,1155,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 157 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,559,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
   Behavioral - irritability
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 115,419,1955
 
                            *** END OF RECORD ***