*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UK4250000
CHEMICAL NAME : Propyne
CAS REGISTRY NUMBER : 74-99-7
BEILSTEIN REFERENCE NO. : 0878138
REFERENCE : 4-01-00-00958 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C3-H4
MOLECULAR WEIGHT : 40.07
WISWESSER LINE NOTATION : 2UU1
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Acetylene, methyl-
* Allylene
* Methyl acetylene
* Propine
* Propyne
* 1-Propyne
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >42000 ppm/6H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 15,20,1957
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28700 ppm/6H/26W-I
TOXIC EFFECTS :
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - other changes
Related to Chronic Data - death
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 15,20,1957
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 28700 ppm/6H/26W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - general anesthetic
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 15,20,1957
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,335,1994
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 25 pph
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,335,1994
*** REVIEWS ***
ACGIH TLV-TWA 1640 mg/m3 (1000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1000 ppm (1650 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,153,1971
OSHA PEL (Gen Indu):8H TWA 1000 ppm (1650 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1000 ppm (1650 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1000 ppm (1650 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1000 ppm (1650 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1000 ppm (1650 mg/m3);STEL 1250 ppm JAN 1993
OEL-BELGIUM:TWA 1000 ppm (1640 mg/m3);STEL 1250 ppm (2050 mg/m3) JAN 1993
OEL-DENMARK:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-FINLAND:TWA 1000 ppm (1650 mg/m3);STEL 1250 ppm (2065 mg/m3) JAN 1993
OEL-FRANCE:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-GERMANY:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL-TURKEY:TWA 1000 ppm (1650 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYL ACETYLENE-air:10H TWA 1000 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 46435
No. of Facilities: 311 (estimated)
No. of Industries: 9
No. of Occupations: 13
No. of Employees: 5033 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 46435
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 7
No. of Employees: 119 (estimated)
No. of Female Employees: 6 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***