*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UK8008000 CHEMICAL NAME : Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, monosodium salt, (5Z,11-alpha,13E,15S)- CAS REGISTRY NUMBER : 53697-17-9 LAST UPDATED : 198910 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H31-O5.Na MOLECULAR WEIGHT : 374.50 WISWESSER LINE NOTATION : L5VTJ B2U4VQ C1U1YQ5 DQ &-NA- COMPOUND DESCRIPTOR : Reproductive Effector SYNONYMS/TRADE NAMES : * (5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid monosodium salt * PGE2 sodium salt * Prostaglandin E2 sodium salt * U 12062A *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 14,322,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 14,322,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - rabbit DOSE : 1 mg/kg SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,479,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - hamster DOSE : 2 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,479,1975 *** END OF RECORD ***