*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UK8021000
CHEMICAL NAME           : Prosta-5,13-dien-1-oic acid,
                          9,11,15-trihydroxy-15-methyl-,
                          (5Z,9-alpha,11-alpha,13E,15S)-
CAS REGISTRY NUMBER     : 35700-23-3
BEILSTEIN REFERENCE NO. : 2949991
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C21-H36-O5
MOLECULAR WEIGHT        : 368.57
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Carboprost
   * 15-ME-PGF2-alpha
   * Methyl-pgf2-alpha
   * 15(S)-15-Methyl pgf2-alpha
   * 15-Methylprostaglandin F2-alpha
   * 15(S)-Methylprostaglandin F2-alpha
   * 15(S)-15-Methyl-prostaglandin F2-alpha
   * (15S)-15-Methylprostaglandin F2-alpha
   * Prostin 15M
   *   (5Z,9-alpha,11-alpha,13E,15S)-9,11,15-Trihydroxy-15-methylprosta-5,13-di
     en-1-oic acid
   * U 32921E
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 5 ug/kg
SEX/DURATION            : female 14 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth.
   (London, UK)  V.68-81, 1961-74.  For publisher information, see BJOGAS.
   Volume(issue)/page/year: 79,737,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 12 ug/kg
SEX/DURATION            : female 30 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 14,785,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 10 ug/kg
SEX/DURATION            : female 13 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth.
   (London, UK)  V.68-81, 1961-74.  For publisher information, see BJOGAS.
   Volume(issue)/page/year: 79,737,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE                    : 60 ug/kg
SEX/DURATION            : female 42 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 21,273,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE                    : 10 ug/kg
SEX/DURATION            : female 15 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth.
   (London, UK)  V.68-81, 1961-74.  For publisher information, see BJOGAS.
   Volume(issue)/page/year: 79,737,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ug/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   8,540,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 500 ug/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 151,575,1976

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 113,130,1972

 
                            *** END OF RECORD ***