*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO3506000
CHEMICAL NAME           : 4(3H)-Pteridinone,
                          2-amino-6-(L-erythro-1,2-dihydroxypropyl)-
CAS REGISTRY NUMBER     : 22150-76-1
LAST UPDATED            : 199509
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C9-H11-N5-O3
MOLECULAR WEIGHT        : 237.25
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Biopterin
   * L-Biopterin
   * 6-Biopterin
   * 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-, (S-(R*,S*))-
   * Pterin H B2
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 6,180,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 879 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in bladder weight
   Endocrine - changes in spleen weight
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 6,180,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 128,147,1984
 
                            *** END OF RECORD ***