*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UO7451000 CHEMICAL NAME : 9H-Purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- CAS REGISTRY NUMBER : 23590-99-0 LAST UPDATED : 199801 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C10-H10-N4-O5 MOLECULAR WEIGHT : 266.24 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * Diglycoaldehyde * (R,R)-alpha-(1-Formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-9H-purine-9-ace taldehyde * Inosine dialdehyde * INOX * NSC 118994 * 9H-Purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,(R*,R*))- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 567 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Blood - normocytic anemia Blood - thrombocytopenia REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-166125 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 625 mg/kg/5D-I TOXIC EFFECTS : Blood - leukopenia Blood - changes in bone marrow (not otherwise specified) Kidney, Ureter, Bladder - other changes REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB82-166125 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 830 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2188,1977 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 830 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,2188,1977 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,1717,1985 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,1717,1985 *** END OF RECORD ***