*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO7451000
CHEMICAL NAME           : 9H-Purine-9-acetaldehyde,
                          alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-,
                          (R,R)-
CAS REGISTRY NUMBER     : 23590-99-0
LAST UPDATED            : 199801
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C10-H10-N4-O5
MOLECULAR WEIGHT        : 266.24
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Diglycoaldehyde
   *   (R,R)-alpha-(1-Formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-9H-purine-9-ace
     taldehyde
   * Inosine dialdehyde
   * INOX
   * NSC 118994
   * 9H-Purine-9-acetaldehyde,  
   alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,(R*,R*))-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 567 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - normocytic anemia
   Blood - thrombocytopenia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-166125
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 625 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - changes in bone marrow (not otherwise specified)
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-166125
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 830 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2188,1977
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 830 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2188,1977
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,1717,1985
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,1717,1985
 
                            *** END OF RECORD ***