*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8151300
CHEMICAL NAME           : Androst-4-ene-3,17-dione, 9-fluoro-11-beta-hydroxy-
CAS REGISTRY NUMBER     : 357-09-5
BEILSTEIN REFERENCE NO. : 3159067
REFERENCE               : 4-08-00-02161 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H25-F-O3
MOLECULAR WEIGHT        : 320.44
WISWESSER LINE NOTATION : L E5 B666 FV OV MUTJ A1 BF CQ E1
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Androst-4-ene-3,17-dione, 9-fluoro-11-hydroxy-, (11-beta)-
   * Fluorohydroxyandrostenedione
   * 9-alpha-Fluoro-11-beta-hydroxy-4-androstene-3,17-dione
   * U-5438
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 3-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - abortion
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 39,319,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 39,319,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 12 mg/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 39,319,1974
 
                            *** END OF RECORD ***