*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8510000
CHEMICAL NAME           : Androst-4-en-3-one,
                          17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)-
CAS REGISTRY NUMBER     : 79-64-1
LAST UPDATED            : 199510
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C23-H32-O2
MOLECULAR WEIGHT        : 340.55
WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FQ F1UU2 L1 -A&L -B&AEF
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Androst-4-en-3-one, 17-hydroxy-6-methyl-17-(1-propynyl)-,  
   (6-alpha,17-beta)-
   * Dimethisteron
   * Dimethisterone
   * 6-alpha,21-Dimethyl-17-alpha-ethinyltestosterone
   * 6-alpha,21-Dimethylethisterone
   * 6-alpha,21-Dimethyl-17-beta-hydroxy-17-alpha-pregn-4-en-20-yn-3-one
   * 17-alpha-Ethynyl-6-alpha,21-dimethyltestosterone
   * 17-alpha-Ethynyl-17-hydroxy-6-alpha,21-dimethylandrost-4-en-3-one
   * (6-alpha,17-beta)-17-Hydroxy-6-methyl-17-(1-propynyl)-androst-4-en-3-one
   * 17-beta-Hydroxy-6-alpha-methyl-17-(1-propynyl)androst-4-en-3-one
   * Lutogan
   * 6-alpha-Methyl-17-alpha-propynyltestosterone
   * 6-alpha-Methyl-17-(1-propynyl)testosterone
   * P-5048
   * 17-alpha-Pregn-4-en-20-yn-3-one, 6-alpha,21-dimethyl-17-hydroxy-
   * Secrosteron
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 17-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ECJPAE Endocrinologia Japonica.  (Japan Pub. Trading Co., Ltd., POB 5030,
   Tokyo International, Tokyo, Japan)  V.1-    1954-  Volume(issue)/page/year:
   24,77,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 175 mg/kg
SEX/DURATION            : female 15-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ACENA7 Acta Endocrinologica (Copenhagen).  (Periodica, Skolegade 12 E,
   DK-2500 Valby, Denmark) V.1-    1948-  Volume(issue)/page/year: 38,128,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,57,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 28 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,57,1972

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 21,377,1979

 
                            *** END OF RECORD ***