*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : BV8510000 CHEMICAL NAME : Androst-4-en-3-one, 17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)- CAS REGISTRY NUMBER : 79-64-1 LAST UPDATED : 199510 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C23-H32-O2 MOLECULAR WEIGHT : 340.55 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 E1 FQ F1UU2 L1 -A&L -B&AEF COMPOUND DESCRIPTOR : Tumorigen Reproductive Effector Hormone SYNONYMS/TRADE NAMES : * Androst-4-en-3-one, 17-hydroxy-6-methyl-17-(1-propynyl)-, (6-alpha,17-beta)- * Dimethisteron * Dimethisterone * 6-alpha,21-Dimethyl-17-alpha-ethinyltestosterone * 6-alpha,21-Dimethylethisterone * 6-alpha,21-Dimethyl-17-beta-hydroxy-17-alpha-pregn-4-en-20-yn-3-one * 17-alpha-Ethynyl-6-alpha,21-dimethyltestosterone * 17-alpha-Ethynyl-17-hydroxy-6-alpha,21-dimethylandrost-4-en-3-one * (6-alpha,17-beta)-17-Hydroxy-6-methyl-17-(1-propynyl)-androst-4-en-3-one * 17-beta-Hydroxy-6-alpha-methyl-17-(1-propynyl)androst-4-en-3-one * Lutogan * 6-alpha-Methyl-17-alpha-propynyltestosterone * 6-alpha-Methyl-17-(1-propynyl)testosterone * P-5048 * 17-alpha-Pregn-4-en-20-yn-3-one, 6-alpha,21-dimethyl-17-hydroxy- * Secrosteron *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 100 mg/kg SEX/DURATION : female 17-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 175 mg/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 70 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 28 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,377,1979 *** END OF RECORD ***