*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BV8530000
CHEMICAL NAME           : Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)-
CAS REGISTRY NUMBER     : 651-48-9
LAST UPDATED            : 199604
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H28-O5-S
MOLECULAR WEIGHT        : 368.53
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Androst-5-en-17-one, 3-beta-hydroxy-, hydrogen sulfate
   * Dehydroandrosterone sulfate
   * Dehydroepiandrosterone monosulfate
   * Dehydroepiandrosterone-sulfate
   * Dehydroepiandrosterone 3-sulfate
   * Dehydroepiandrosterone 3-beta-sulfate
   * Dehydroisoandrosterone sulfate
   * DHEA sulfate
   * 3-O-Sulfodehydroepiandrosterone
   * (3-beta)-3-(Sulfooxy)androst-5-en-17-one
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 655 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 13,414,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 293 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 13,414,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 25200 ug/kg/28D-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Endocrine - effect on menstrual cycle
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 57,912,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 12 mg/kg
SEX/DURATION            : female 39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - biochemical and metabolic
   Endocrine - androgenic
REFERENCE :
   NISFAY Nippon Sanka Fujinka Gakkai Zasshi.  Journal of the Japan Society of
   Obstetrics and Gynecology.  (Nippon Sanka Fujinka Gakkai Zasshi, Hoken
   Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan)
   V.1-    1949-  Volume(issue)/page/year: 41,806,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 10-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Maternal Effects - other effects
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 13,414,1993
 
                            *** END OF RECORD ***