*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : BV8530000 CHEMICAL NAME : Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)- CAS REGISTRY NUMBER : 651-48-9 LAST UPDATED : 199604 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C19-H28-O5-S MOLECULAR WEIGHT : 368.53 COMPOUND DESCRIPTOR : Reproductive Effector Human SYNONYMS/TRADE NAMES : * Androst-5-en-17-one, 3-beta-hydroxy-, hydrogen sulfate * Dehydroandrosterone sulfate * Dehydroepiandrosterone monosulfate * Dehydroepiandrosterone-sulfate * Dehydroepiandrosterone 3-sulfate * Dehydroepiandrosterone 3-beta-sulfate * Dehydroisoandrosterone sulfate * DHEA sulfate * 3-O-Sulfodehydroepiandrosterone * (3-beta)-3-(Sulfooxy)androst-5-en-17-one *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 655 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 293 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 25200 ug/kg/28D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Endocrine - effect on menstrual cycle Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 57,912,1992 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 12 mg/kg SEX/DURATION : female 39 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - biochemical and metabolic Endocrine - androgenic REFERENCE : NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 41,806,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 200 mg/kg SEX/DURATION : female 10-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 *** END OF RECORD ***