*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : BW8225000 CHEMICAL NAME : Aniline, N,N-bis(2-chloroethyl)- CAS REGISTRY NUMBER : 553-27-5 BEILSTEIN REFERENCE NO. : 0880463 REFERENCE : 4-12-00-00253 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C10-H13-Cl2-N MOLECULAR WEIGHT : 218.14 WISWESSER LINE NOTATION : G2NR&2G COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Aniline mustard * Anilinlost * N,N-Bis(2-chloroethyl)aniline * N,N-Bis(2-chloroethyl)benzenamine * beta,beta'-Dichlorodiethylaniline * N,N,-Di(2-chloroethyl)aniline * Lymphchin * Lymphocin * Lymphoquin * NSC-18429 * Phenylbis(2-chloroethylamine) * TL 476 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 239 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,469,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,167,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 123 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,469,1969 TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/m3/10M TOXIC EFFECTS : Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema REFERENCE : NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,DEC1942 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 52 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,469,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 5,41,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL. Volume(issue)/page/year: 5,203,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 375 mg/kg/35D-I TOXIC EFFECTS : Behavioral - food intake (animal) Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,469,1969 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 375 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death REFERENCE : NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,469,1969 ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 30 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,78,1984 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal *** END OF RECORD ***