*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BX7175000
CHEMICAL NAME           : Aniline, N,N-dimethyl-p-nitroso-
CAS REGISTRY NUMBER     : 138-89-6
BEILSTEIN REFERENCE NO. : 0607293
REFERENCE               : 4-12-00-01558 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H10-N2-O
MOLECULAR WEIGHT        : 150.20
WISWESSER LINE NOTATION : ONR DN1&1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Accelerine
   * Benzenamine, N,N-dimethyl-4-nitroso-
   * p-(Dimethylamino)nitrosobenzene
   * 4-(Dimethylamino)nitrosobenzene
   * N,N-Dimethyl-p-nitrosoaniline
   * N,N-Dimethyl-4-nitrosobenzenamine
   * Dimethyl(p-nitrosophenyl)amine
   * NCI-C01821
   * NDMA
   * p-Nitroso-N,N-dimethylaniline
   * 4-Nitrosodimethylaniline
   * Paranitrosodimethylanilide
   * Ultra Brilliant Blue P
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 13,87,1931
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7300 mg/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   PUOMA5 Proceedings of the University of Otago Medical School.  (Otago
   Medical School Research Soc., Box 913, Dunedin, New Zealand)  V.1-    1922-
   Volume(issue)/page/year: 46,68,1968
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***