*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : BY4550000
CHEMICAL NAME : Aniline, N-methyl-
CAS REGISTRY NUMBER : 100-61-8
LAST UPDATED : 199712
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C7-H9-N
MOLECULAR WEIGHT : 107.17
WISWESSER LINE NOTATION : 1MR
SYNONYMS/TRADE NAMES :
* Anilinomethane
* Benzenamine, N-methyl-
* (Methylamino)benzene
* N-Methylaminobenzene
* Methylaniline
* N-Methylaniline
* N-Methylbenzenamine
* Methylphenylamine
* N-Methylphenylamine
* Monomethylaniline
* N-Monomethylaniline
* Monomethyl aniline
* N-Phenylmethylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 24 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,1,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 271,16,1941
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 271,16,1941
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 ug/m3/24H/14W-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Liver - liver function tests impaired
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 34(3),7,1969
*** REVIEWS ***
ACGIH TLV-TWA 2.2 mg/m3 (0.5 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2 ppm (9 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,174,1971
OSHA PEL (Gen Indu):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2 ppm (9 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 2 ppm (9 mg/m3);Skin JAN 1993
OEL-AUSTRALIA:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.5 ppm (2.2 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 0.5 ppm (2.25 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 ppm (2 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.5 ppm (2.2 mg/m3);STEL 1.0 ppm;Skin JAN 1993
OEL-TURKEY:TWA 2 ppm (9 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MONOMETHYL ANILINE-air:10H TWA 0.5 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3740
No. of Facilities: 82 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 82 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Monomethylaniline, 3511
*** END OF RECORD ***