*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : BY5425000
CHEMICAL NAME : Aniline, 4,4'-methylenedi-
CAS REGISTRY NUMBER : 101-77-9
BEILSTEIN REFERENCE NO. : 0474706
REFERENCE : 4-13-00-00390 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 49
MOLECULAR FORMULA : C13-H14-N2
MOLECULAR WEIGHT : 198.29
WISWESSER LINE NOTATION : ZR D1R DZ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* 4-(4-Aminobenzyl)aniline
* Ancamine TL
* Araldite hardener 972
* Avaldite HT 972
* Benzenamine, 4,4'-methylenebis-
* Bis-p-aminofenylmethan
* Bis(p-aminophenyl)methane
* Bis(4-aminophenyl)methane
* Curithane
* Dadpm
* DAPM
* p,p'-Diaminodifenylmethan
* 4,4'-Diaminodiphenylmethan
* Diaminodiphenylmethane
* p,p'-Diaminodiphenylmethane
* Di-(4-aminophenyl)methane
* Dianilinomethane
* 4,4'-Diphenylmethanediamine
* Epicure DDM
* Epikure DDM
* HT 972
* Jeffamine AP-20
* Methylenebis(aniline)
* 4,4'-Methylenebisaniline
* 4,4'-Methylenebis(benzeneamine)
* Methylenedianiline
* p,p'-Methylenedianiline
* 4,4'-Methylenedianiline
* 4,4-Methylenedianiline
* Sumicure M
* Tonox
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,481,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 8420 ug/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Liver - jaundice, other or unclassified
Liver - other changes
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,514,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 517 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539752
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 193 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
57,247,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 745 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
Volume(issue)/page/year: 14,677,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 11,185,1978
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 58,167,1907
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555064
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16800 mg/kg/40W-C
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,145,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6972 mg/kg/12W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
APPFAR Acta Poloniae Pharmaceutica (English Translation). Translation of
APPHAX. (Warsaw, Poland) V.20-29, 1963-72. Discontinued.
Volume(issue)/page/year: 26,352,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 456 mg/kg/15W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - interstitial nephritis
Blood - normocytic anemia
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 11,367,1991
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 219,1162,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1410 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
57,247,1970
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 250 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,123,1979
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 370 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 2,1317,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,683,1988
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 9 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 108,225,1983
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.81 mg/m3 (0.1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 39,347,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 39,347,1986
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE85-017376
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (0.8 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.1 ppm (0.81 mg/m3);Skin;Carcinogen JAN 1993
OEL-DENMARK:TWA 0.1 ppm (0.8 mg/m3) JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.8 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 4,4'-METHYLENEDIANILINE-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83609
No. of Facilities: 363 (estimated)
No. of Industries: 16
No. of Occupations: 27
No. of Employees: 9163 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83609
No. of Facilities: 741 (estimated)
No. of Industries: 25
No. of Occupations: 30
No. of Employees: 15170 (estimated)
No. of Female Employees: 3407 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH CURRENT INTELLIGENCE BULLETIN 8, 1976 AND BULLETIN 47, 1986
NIOSH Analytical Method, 1994: 4,4'-Methylenedianiline, 5029
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
OSHA ANALYTICAL METHOD #ID-57
*** END OF RECORD ***