*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BY6825000
CHEMICAL NAME           : Aniline, m-nitro-
CAS REGISTRY NUMBER     : 99-09-2
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C6-H6-N2-O2
MOLECULAR WEIGHT        : 138.14
WISWESSER LINE NOTATION : ZR CNW
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Amarthol Fast Orange R Base
   * m-Aminonitrobenzene
   * 1-Amino-3-nitrobenzene
   * Azobase MNA
   * Benzenamine, 3-nitro-
   * C.I. 37030
   * C.I. Azoic Diazo Component 7
   * Daito Orange Base R
   * Devol Orange R
   * Diazo Fast Orange R
   * Fast Orange Base R
   * Fast Orange M Base
   * Fast Orange MM Base
   * Fast Orange R Base
   * Fast Orange R Salt
   * Hiltonil Fast Orange R Base
   * Naphtoelan Orange R Base
   * Nitranilin
   * m-Nitroaminobenzene
   * 3-Nitroaniline
   * 3-Nitrobenzenamine
   * m-Nitrophenylamine
   * Orange Base IRGA I
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 535 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMRL** Aerospace Medical Research Laboratory Report.  (Aerospace Technical
   Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
   Volume(issue)/page/year: TR-72-62,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 308 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMRL** Aerospace Medical Research Laboratory Report.  (Aerospace Technical
   Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
   Volume(issue)/page/year: TR-72-62,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JIDHAN Journal of Industrial Hygiene.  (Cambridge, MA)  V.1-17, 1919-35. For
   publisher information, see AEHLAU.  Volume(issue)/page/year: 2,247,1920
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   VKMGA7 Voprosy Kommunal'noi Gigieny.  Problems of Communal Hygiene.  (Kiev,
   USSR)  V.6, 1966. For publisher information, see GNAMAP.
   Volume(issue)/page/year: 6,89,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : 562 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg/28D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in spleen weight
   Blood - normocytic anemia
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (109),72,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2940 mg/kg/3W-I
TOXIC EFFECTS :
   Blood - other changes
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   VKMGA7 Voprosy Kommunal'noi Gigieny.  Problems of Communal Hygiene.  (Kiev,
   USSR)  V.6, 1966. For publisher information, see GNAMAP.
   Volume(issue)/page/year: 6,89,1966
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   IJCMDW International Journal of Cosmetic Science.  (Blackwell Scientific
   Pub. Inc., 52 Beacon St., Boston, MA 02108)  V.1-    1979-
   Volume(issue)/page/year: 7,277,1985
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 170,11,1986

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   47,26992,82

   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***