*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : BZ6600000 CHEMICAL NAME : p-Anisidine, hydrochloride CAS REGISTRY NUMBER : 20265-97-8 LAST UPDATED : 199712 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C7-H9-N-O.Cl-H MOLECULAR WEIGHT : 159.63 WISWESSER LINE NOTATION : ZR DO1 &GH COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * p-Aminoanisole hydrochloride * 4-Aminoanisole hydrochloride * 1-Amino-4-methoxybenzene hydrochloride * 4-Anisidine hydrochloride * p-Anisidine monohydrochloride * p-Anisylamine hydrochloride * Benzenamine, 4-methoxy-, hydrochloride * 4-Methoxy-1-aminobenzene hydrochloride * p-Methoxyaniline hydrochloride * 4-Methoxyaniline hydrochloride * 4-Methoxybenzenamine hydrochloride * 4-Methoxybenzeneamine hydrochloride * p-Methoxyphenylamine hydrochloride * NCI-C03758 *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2163 gm/kg/1Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - tumors REFERENCE : IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 116 gm/kg/92W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-116,1978 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 33 ug/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl 5),1,1985 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 1 mg/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl 5),1,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-116,78 NCI Carcinogenesis Bioassay (feed);inadequate studies:rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-116,78 NTP Carcinogenesis studies; laboratory assigned, October 1997 NTP Carcinogenesis studies; on test (prechronic studies), October 1997 *** END OF RECORD ***