*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO8428200
CHEMICAL NAME           : 1H-Purine-2,6-dione,
                          3,7-dihydro-1,3-dimethyl-7-(2-(1-piperazinyl)ethyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 53499-66-4
LAST UPDATED            : 198505
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C13-H20-N6-O2.2Cl-H
MOLECULAR WEIGHT        : 365.31
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7-beta-Piperazinoethyltheophylline dihydrochloride
   * Theophylline, 7-(2-(1-piperazinyl)ethyl)-, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 725 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   APJUA8 Acta Pharmaceutica Jugoslavica.  (FDH, Masarykova 2, 41000 Zagreb,
   Yugoslavia)  V.1-41, 1951-1991.  Volume(issue)/page/year: 24,89,1974
 
                            *** END OF RECORD ***