*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UO9000000
CHEMICAL NAME           : 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-,
                          monohydrate
CAS REGISTRY NUMBER     : 7143-67-1
LAST UPDATED            : 199012
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C11-H14-N4-O4-S.H2-O
MOLECULAR WEIGHT        : 316.37
WISWESSER LINE NOTATION : T56 BN DN FN HNJ IS1 D- BT5OTJ CQ DQ E1Q &QH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6-Methylthio-9-beta-D-ribofuranosyl-9H-purine monohydrate
   * NSC-40774
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,130,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,130,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 501 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,130,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 437 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,130,1965
 
                            *** END OF RECORD ***