*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UP0175000 CHEMICAL NAME : 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-erytho-pentofuranosyl)-, monohydrate CAS REGISTRY NUMBER : 64039-27-6 LAST UPDATED : 199707 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C10-H13-N5-O3-S.H2-O MOLECULAR WEIGHT : 301.36 WISWESSER LINE NOTATION : T56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1 &QH COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * beta-Deoxythioguanosine monohydrate * beta-2'-Deoxy-6-thioguanosine monohydrate * Guanosine, 2'-deoxy-6-thio-, monohydrate * NSC-71261 * 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-ribofuranosyl)-, hydrate * beta-TGdR monohydrate * beta-Thioguanine deoxyriboside monohydrate *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 467 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - tremor Gastrointestinal - hypermotility, diarrhea REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,522,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 354 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - tremor Gastrointestinal - hypermotility, diarrhea REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,522,1969 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 142 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes Endocrine - hyperglycemia REFERENCE : CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,41,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg/5D-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death REFERENCE : CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,41,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg/5D-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death REFERENCE : CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,41,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 13500 ug/kg/5D-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from large intestine Blood - leukopenia REFERENCE : NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,522,1969 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 17760 ug/kg/2W-I TOXIC EFFECTS : Endocrine - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death REFERENCE : CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,41,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 39200 ug/kg/14D-I TOXIC EFFECTS : Blood - normocytic anemia Blood - leukopenia Related to Chronic Data - death REFERENCE : CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,41,1973 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1092 mg/kg/1Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-57,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 175 mg/kg/8W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,3069,1973 *** END OF RECORD ***