*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UP0200000
CHEMICAL NAME           : 9H-Purine-6-thiol, 2-amino-9-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER     : 85-31-4
LAST UPDATED            : 199410
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H13-N5-O4-S
MOLECULAR WEIGHT        : 299.34
WISWESSER LINE NOTATION : T56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1Q
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Amino-6-mercaptopurine ribonucleoside
   * 2-Amino-6-mercaptopurine riboside
   * 2-Amino-6-mercapto-9(beta-D-ribofuranosyl)purine
   * 2-Amino-9-(beta-D-ribofuranosyl)purine-6-thiol
   * 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-thiol
   * Guanosine, 6-thio-
   * 6-Mercaptoguanosine
   * NSC-29422
   * 6H-Purine-6-thione, 2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-
   * Ribosylthioguanine
   * SK 18615
   * SRI 759
   * 6-Thiodeoxyguanosine
   * 6-Thioguanine ribonucleoside
   * Thioguanine riboside
   * 6-Thioguanine riboside
   * Thioguanosine
   * 6-Thioguanosine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 156 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   7,69,1970

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
   Springer, 1975  Volume(issue)/page/year: -,49,1975

 
                            *** END OF RECORD ***