*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UP0745000
CHEMICAL NAME           : 9H-Purine-6(1H)-thione,
                          2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-
CAS REGISTRY NUMBER     : 2133-81-5
OTHER CAS REGISTRY NOS. : 2946-51-2
LAST UPDATED            : 199703
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C10-H13-N5-O3-S
MOLECULAR WEIGHT        : 283.34
WISWESSER LINE NOTATION : T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * alpha-Deoxythioguanosine
   * alpha-2'-Deoxythioguanosine
   * alpha-2'-Deoxy-6-thioguanosine
   * NSC-71851
   * 6H-Purine-6-thione,  
   2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-1,9-dihydro-
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1 gm/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Related to Chronic Data - death
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   5,9,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1500 mg/kg/33D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   5,9,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 3 gm/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - agranulocytosis
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CCYPBY Cancer Chemotherapy Reports, Part 3.  (Washington, DC)  V.1-6,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   5,9,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 4 umol/L
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 27,17,1986
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,1103,1975
 
TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,1103,1975
 
                            *** END OF RECORD ***