*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UP6000000
CHEMICAL NAME           : 2H-Pyran-2-acetic acid,
                          6-(2-(2-(5-(6-ethyl-3,6-dihydro-5-methyl-2H-pyran-2-y
                          l)-3-methyl-
                          1,4-hexadienyl)-3-methylcyclopropyl)ethenyl)tetrahydr
                          o-4,5-dihydroxy-, monosodium salt
CAS REGISTRY NUMBER     : 67999-78-4
LAST UPDATED            : 199209
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C28-H41-O6.Na
MOLECULAR WEIGHT        : 496.68
WISWESSER LINE NOTATION : T6O CUTJ B2 C1 FY1&1U1- AL3TJ B1 C1U1- BT6OTJ CQ DQ
                          F1VO &-NA-
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Ambruticin sodium salt
   * Antibiotic acid S sodium salt
   * W7783 sodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 30,371,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 30,371,1977
 
                            *** END OF RECORD ***