*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UP7525000 CHEMICAL NAME : Pyran-3,4-dicarboxylic anhydride, tetrahydro-2-methyl-6-(tetrahydro-2,5-dioxo-3-furyl)- , polymer CAS REGISTRY NUMBER : 26427-28-1 LAST UPDATED : 199606 DATA ITEMS CITED : 6 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * NSC-46015 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140) Volume(issue)/page/year: -,38,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 121 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold REFERENCE : NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140) Volume(issue)/page/year: -,38,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 106 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold REFERENCE : NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140) Volume(issue)/page/year: -,38,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 112 mg/kg/28D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in both tubules and glomeruli Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140) Volume(issue)/page/year: -,38,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 448 mg/kg/28D-I TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140) Volume(issue)/page/year: -,38,1964 ** MUTATION DATA ** TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - mouse Liver DOSE/DURATION : 2 gm/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,1610,1978 *** END OF RECORD ***