*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ0520000
CHEMICAL NAME           : 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-,
                          (R)-, mixt. with 5,6-dihydro-4-methoxy-
                          6-phenethyl-2H-pyran-2-one and
                          4-methoxy-6-(p-methoxystyryl)-2H-pyran-2-one (2:2:1)
SUBSTANCE DEFINITION :
   A mixture of the drug kavain and its principal contaminants
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C14-H14-O3.C14-H16-O3.1/2C15-H14-O4
MOLECULAR WEIGHT        : 591.68
WISWESSER LINE NOTATION : T6OV CUTJ DO1 F2R 2 &T6OV CUTJ DO1 F1U1R 2 &T6OVJ DO1
                          F1U1R DO1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Kavain, dihydrokavin and yangonin (2:2:1)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 26,692,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2600 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 26,692,1971
 
                            *** END OF RECORD ***