*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ2010000
CHEMICAL NAME           : Pyrazinamine, N-nitroso-
CAS REGISTRY NUMBER     : 103829-56-7
BEILSTEIN REFERENCE NO. : 0774915
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C4-H4-N4-O
MOLECULAR WEIGHT        : 124.12
SYNONYMS/TRADE NAMES :
   * N-Nitrosopyrazinamine
   * NSC 361456
   * Pyrazine diazohydroxide
   * 2-Pyrazine diazohydroxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB88-239900
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Blood - leukopenia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 29,511,1988
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - changes in bone marrow (not otherwise specified)
   Related to Chronic Data - death
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB88-239900
 
                            *** END OF RECORD ***