*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UQ2010000 CHEMICAL NAME : Pyrazinamine, N-nitroso- CAS REGISTRY NUMBER : 103829-56-7 BEILSTEIN REFERENCE NO. : 0774915 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C4-H4-N4-O MOLECULAR WEIGHT : 124.12 SYNONYMS/TRADE NAMES : * N-Nitrosopyrazinamine * NSC 361456 * Pyrazine diazohydroxide * 2-Pyrazine diazohydroxide *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 176 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 29,511,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg/5D-I TOXIC EFFECTS : Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death Related to Chronic Data - changes in testicular weight REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB88-239900 *** END OF RECORD ***