*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ2278500
CHEMICAL NAME           : Pyrazinecarboxamide,
                          3,5-diamino-N-(aminoiminomethyl)-6-chloro-,
                          monohydrochloride, mixt. with
                          6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazene-7-sulf
                          onamide 1,1-dioxide
CAS REGISTRY NUMBER     : 57017-78-4
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C7-H8-Cl-N3-O4-S2.C6-H8-Cl-N7-O.Cl-H
MOLECULAR WEIGHT        : 563.87
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Amiloride hydrochloride-hydrochlorothiazide
   * Amitrid
   * Moduretic
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 5500 ug/kg/5D-I
TOXIC EFFECTS :
   Behavioral - headache
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - changes in sodium
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,634,1986
 
                            *** END OF RECORD ***