*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ4903600
CHEMICAL NAME           : 1H-Pyrazole-1-acetamide,
                          N-(3-(diethylamino)propyl)-4,5-diphenyl-,
                          (E)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 115436-74-3
LAST UPDATED            : 199403
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C24-H30-N4-O.C4-H4-O4
MOLECULAR WEIGHT        : 506.66
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-(3-(Diethylamino)propyl)-4,5-diphenyl-1H-pyrazole-1-acetamide  
   (E)-2-butenedioate (1:1)
   * Ipazilide fumarate
   * WIN 54177-4
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,581,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29200 mg/kg/1Y-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in thyroid weight
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   20,147,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9280 mg/kg/29D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - proteinuria
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,581,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 870 mg/kg/29D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Liver - changes in liver weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,581,1992
 
                            *** END OF RECORD ***