*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ4920000
CHEMICAL NAME           : Pyrazole-5-acetic acid, 3,4-diphenyl-1-isobutyl-,
                          sodium salt
LAST UPDATED            : 199801
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H21-N2-O2.Na
MOLECULAR WEIGHT        : 356.43
WISWESSER LINE NOTATION : T5NNJ A1Y1&1 CR& DR& E1VO &-NA-
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bufezolac sodium
   * 3,4-Diphenyl-1-isobutylpyrazole-5-acetic acid sodium salt
   * 1-Isobutyl-3,4-diphenylpyrazole-5-acetic acid sodium salt
   * LM 22070 sodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 46 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 238,305,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 238,305,1979
 
                            *** END OF RECORD ***