*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ6360000
CHEMICAL NAME           : 1H-Pyrazole-5-carboxamide,
                          4-hydroxy-3-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER     : 30868-30-5
LAST UPDATED            : 199112
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C9-H13-N3-O6
MOLECULAR WEIGHT        : 259.25
WISWESSER LINE NOTATION : T5OTJ B1Q CQ DQ E- CT5MNJ DQ EVZ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Antibiotic A 23813
   * Compound 47599
   * 4-Hydroxy-3-beta-D-ribofuranosyl-1H-pyrazole-5-carboxamide
   * NSC 143095
   * Pirazofurin
   * Pyrazofurin
   * Pyrazomycin
   * beta-Pyrazomycin
   * 3-beta-D-Ribofuranosyl-4-hydroxypyrazole-5-carboxamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 108 mg/kg/5D
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 62,1569,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 48 mg/kg/5D
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 84 mg/kg/5D
TOXIC EFFECTS :
   Blood - changes in bone marrow (not otherwise specified)
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 108 mg/kg/5D
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 144 mg/kg/5D
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - dehydration
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,2806,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3807,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   31,1109,1982
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   31,1109,1982
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - guinea pig Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   JBTOEB Journal of Biochemical Toxicology. (VCH Publishers, Inc., 220 E. 23rd
   St., Suite 909, New York, NY USA 10010)  V.1-    1986-
   Volume(issue)/page/year: 6,19,1991
 
                            *** END OF RECORD ***