*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ5600000
CHEMICAL NAME           : Pyrazole, 3-(2-aminoethyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 138-92-1
LAST UPDATED            : 199404
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H9-N3.2Cl-H
MOLECULAR WEIGHT        : 184.09
WISWESSER LINE NOTATION : T5MNJ C2Z &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Ametazole dihydrochloride
   * 3-(2-Aminoethyl)pyrazole, dihydrochloride
   * 3-beta-Aminoethylpyrazole dihydrochloride
   * Betazole dihydrochloride
   * Betazole hydrochloride
   * Gastramine
   * Histalog
   * Histalog dihydrochloride
   * 1H-Pyrazole-3-ethanamine, dihydrochloride
   * 3,5-beta-Pyrazoleethylamine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 740 ug/kg/37D-I
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - somnolence (general depressed activity)
   Behavioral - anorexia (human)
REFERENCE :
   AJOPAA American Journal of Ophthalmology.  (Ophthalmic Pub. Co., 435 N.
   Michigan Ave., Suite 1415, Chicago, IL 60611)  Series 3: V.1-    1918-
   Volume(issue)/page/year: 102,275,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 86 ug/kg/6D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AJOPAA American Journal of Ophthalmology.  (Ophthalmic Pub. Co., 435 N.
   Michigan Ave., Suite 1415, Chicago, IL 60611)  Series 3: V.1-    1918-
   Volume(issue)/page/year: 102,274,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 122,685,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 803 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,749,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83995
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 66 (estimated)

 
                            *** END OF RECORD ***