*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ8002500
CHEMICAL NAME           : 1H-Pyrazole-3-propanamide,
                          5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me
                          thyl-
CAS REGISTRY NUMBER     : 103475-41-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H20-Cl-N3-O3
MOLECULAR WEIGHT        : 385.88
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-
     propanamide
   *   3-(5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl)-N-hydroxy-N-methy
     lpropanamide
   * ORF 20485
   * Tepoxalin
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1085 mg/kg/31D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   33,38,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7280 mg/kg/26W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   33,38,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 54600 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   33,38,1996
 
                            *** END OF RECORD ***