*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UQ9625000
CHEMICAL NAME           : 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
CAS REGISTRY NUMBER     : 89-25-8
BEILSTEIN REFERENCE NO. : 0609575
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C10-H10-N2-O
MOLECULAR WEIGHT        : 174.22
WISWESSER LINE NOTATION : T5NMV DHJ BR& E1
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * C.I. Developer 1
   * Developer Z
   * 1-Fenyl-3-methyl-2-pyrazolin-5-on
   * 3-Methyl-1-phenyl-2-pyrazolin-5-one
   * 3-Methyl-1-phenyl-5-pyrazolone
   * NCI-C03952
   * Norantipyrine
   * Norphenazone
   * 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
   * 1-Phenyl-3-methylpyrazolone-5
   * 1-Phenyl-3-methyl-5-pyrazolone
   * 5-Pyrazolone, 3-methyl-1-phenyl-
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,828,1986
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland
   Volume(issue)/page/year: 08FEB1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2012 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 36,27,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 31 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981
 
TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 300 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17,196,1991

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83422
       No. of Facilities: 11 (estimated)
       No. of Industries: 2
       No. of Occupations: 2
       No. of Employees: 114 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83422
       No. of Facilities: 62 (estimated)
       No. of Industries: 5
       No. of Occupations: 5
       No. of Employees: 580 (estimated)
       No. of Female Employees: 137 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-141,78

 
                            *** END OF RECORD ***