*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UR0100000
CHEMICAL NAME : Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one,
4,6-dihydro-1-ethyl-3-methyl-8-phenyl-
CAS REGISTRY NUMBER : 26308-28-1
BEILSTEIN REFERENCE NO. : 0819726
LAST UPDATED : 199703
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C15-H16-N4-O
MOLECULAR WEIGHT : 268.35
COMPOUND DESCRIPTOR : Tumorigen
Drug
SYNONYMS/TRADE NAMES :
* CI-683
* 1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1H)-
one
* Pyrazapon
* Ripazepam
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 81900 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
4,178,1984
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 66,157,1996
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 66,157,1996
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 66,157,1996
*** END OF RECORD ***