*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UR6040000 CHEMICAL NAME : Pyridazine, 3-hydrazino-6-((2-hydroxypropyl)methylamino)-, dihydrochloride CAS REGISTRY NUMBER : 56393-22-7 LAST UPDATED : 199112 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C8-H15-N5-O.2Cl-H MOLECULAR WEIGHT : 270.20 WISWESSER LINE NOTATION : T6NNJ CMZ F1M1YQ1 &GH 2 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Atensil * 3-Hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine dihydrochloride * 6-((2-Hydroxypropyl)methylamino)-3(2H)-pyridazinone hydrazone dihydrochloride * 3-Idrazino-6-(N-(2-idrossipropil)metilamino)piridazina dicloridrato * ISF 2123 * Pildralazine dihydrochloride * Propildazina * Propildazine hydrochloride * Propyldazine hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1230 mg/kg TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 8,295,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 355 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 8,295,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 8,295,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 357 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 8,295,1976 *** END OF RECORD ***