*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR6080000
CHEMICAL NAME           : 5H-Pyridazino(3,4-b)(1,4)benzoxazine,
                          5-methyl-3-(4-methyl-1-piperazinyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 24853-80-3
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C16-H19-N5-O.2Cl-H
MOLECULAR WEIGHT        : 370.32
WISWESSER LINE NOTATION : T C666 BO DNN INJ I1 F- AT6N DNTJ D1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Azaphen hydrochloride
   * 5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino(3,4-b)(1,4)benzoxazine  
   dihydrochloride
   * 2-(4-Methyl-1-piperazinyl)-10-methyl-3,4-diazaphenoxazindihydrochlorid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   114,787,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 490 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   114,787,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   114,787,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 4,118,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   114,787,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 37,2,1974
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und
   Laboratoriums-diagnostik.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr.
   18, 102 Berlin, Ger. Dem. Rep.)  V.109-    1970-  Volume(issue)/page/year:
   114,787,1975
 
                            *** END OF RECORD ***