*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UR8419500
CHEMICAL NAME           : 2-Pyridineacetamide,
                          alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-(2-met
                          hylpropyl)-, (+-)-
CAS REGISTRY NUMBER     : 96513-83-6
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   (+-)-alpha-(2-(Bis(1-methylethyl)amino)ethyl)-alpha-(2-methylpropyl)-2-p
     yridineacetamide
   * CM 7857
   * (+-)-2-(2-(Diisopropylamino)ethyl)-2-isobutyl-2-pyridineacetamide
   * ME 3202
   * Pentisomide
   * Propisomide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,3536,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18200 mg/kg/13W-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,3536,1993
 
                            *** END OF RECORD ***