*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US2800000
CHEMICAL NAME           : Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
CAS REGISTRY NUMBER     : 91-81-6
BEILSTEIN REFERENCE NO. : 0227074
REFERENCE               : 5-22-08-00378 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C16-H21-N3
MOLECULAR WEIGHT        : 255.40
WISWESSER LINE NOTATION : T6NJ BN1R&2N1&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzoxale
   * 2-(Benzyl(2-dimethylaminoethyl)amino)pyridine
   * 2-(N-Benzyl-N-(2-dimethylaminoethyl)amino)pyridine
   * N-Benzyl-N',N'-dimethyl-N-2-pyridylethylenediamine
   * Benzyl-(alpha-pyridyl)-dimethylaethylendiamin
   * N-Benzyl-N-(2-pyridyl)-N',N'-dimethyl ethylenediamine
   * Cizaron
   * beta-Dimethylaminoethyl-2-pyridylaminotoluene
   * beta-Dimethylaminoethyl-2-pyridylbenzylamine
   * N,N-Dimethyl-N'-benzyl-N'-(alpha-pyridyl)ethylenediamine
   * N,N-Dimethyl-N'-benzyl-N'-(2-pyridyl)ethylenediamine
   * Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-
   * NCI-C60662
   * PBZ
   * Piribenzil
   * Pyribenzamine
   * Pyrinamine base
   * Resistamine
   * 2750 R.P.
   * Tonaril
   * Tripelenamine
   * Tripelennamina
   * Tripelennamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,156,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 152 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,237,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,237,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 4,105,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 28,767,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,131,1957
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 33 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 173,229,1986
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 173,229,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 74620
       No. of Facilities: 26 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1324 (estimated)
       No. of Female Employees: 667 (estimated)

 
                            *** END OF RECORD ***