*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : US2800000 CHEMICAL NAME : Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)- CAS REGISTRY NUMBER : 91-81-6 BEILSTEIN REFERENCE NO. : 0227074 REFERENCE : 5-22-08-00378 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C16-H21-N3 MOLECULAR WEIGHT : 255.40 WISWESSER LINE NOTATION : T6NJ BN1R&2N1&1 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Benzoxale * 2-(Benzyl(2-dimethylaminoethyl)amino)pyridine * 2-(N-Benzyl-N-(2-dimethylaminoethyl)amino)pyridine * N-Benzyl-N',N'-dimethyl-N-2-pyridylethylenediamine * Benzyl-(alpha-pyridyl)-dimethylaethylendiamin * N-Benzyl-N-(2-pyridyl)-N',N'-dimethyl ethylenediamine * Cizaron * beta-Dimethylaminoethyl-2-pyridylaminotoluene * beta-Dimethylaminoethyl-2-pyridylbenzylamine * N,N-Dimethyl-N'-benzyl-N'-(alpha-pyridyl)ethylenediamine * N,N-Dimethyl-N'-benzyl-N'-(2-pyridyl)ethylenediamine * Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)- * NCI-C60662 * PBZ * Piribenzil * Pyribenzamine * Pyrinamine base * Resistamine * 2750 R.P. * Tonaril * Tripelenamine * Tripelennamina * Tripelennamine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 152 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,105,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 28,767,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 61 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,131,1957 ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Human Liver DOSE/DURATION : 33 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,229,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74620 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1324 (estimated) No. of Female Employees: 667 (estimated) *** END OF RECORD ***